How does streptomycin sulfate work?How does streptomycin sulfate work?

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Streptomycin sulfate can be used both medically and agriculturally. Currently, it is widely used in agriculture. Streptomycin sulfate is new to most people and does not know its specific use. In fact, streptomycin sulfate is essentially an antibiotic. The drug kills a variety of bacteria, especially the disease caused by Mycobacterium tuberculosis infection. In addition, streptomycin sulfate has the following uses.

Pharmacological effects of streptomycin sulfate

  Streptomycin is also effective against many gram-negative bacilli such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Salmonella, Shigella, Brucella, Pasteurella, etc. With antibacterial effect; Neisseria meningitidis and Neisseria gonorrhoeae are also sensitive to this product. Streptomycin has poor effect on Staphylococcus and other Gram-positive cocci. All groups of Streptococcus, Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product.



  Streptomycin mainly binds to the bacterial ribosomal 30S subunit and inhibits bacterial protein synthesis. Bacteria can easily develop resistance after contact with streptomycin. Combination of streptomycin and other antibacterial or anti-tuberculosis drugs can reduce or delay the development of drug resistance.



  It is well absorbed after intramuscular injection. Mainly distributed in extracellular fluid, and can be distributed to systemic organs and tissues except the brain. The amount of this product reaching cerebrospinal fluid, brain tissue and bronchial secretion fluid is very small; but it can reach bile, pleural effusion, ascites, tuberculous abscess and cheese tissue and can pass through the placenta into fetal tissue. The protein binding rate is 20% to 30%. The blood elimination half-life (t1/2b) is 2.4 to 2.7 hours, and it can be significantly prolonged when renal function decreases. This product is not metabolized in the body and is mainly excreted through glomerular filtration. 80% to 98% is excreted in urine 24 hours after administration, about 1% is excreted from bile, and a small amount is excreted from milk, saliva and sweat. This product can be cleared by hemodialysis in considerable amounts.



The streptomycin sulfate structure

  It is a crystalline powder (white) with relatively stable properties and is easily soluble in water. It can be broken and destroyed when exposed to air, light and heat sources.



The streptomycin sulfate use

 Streptomycin sulfate is used for Gram-negative and Mycobacterium tuberculosis infections. It can be used to treat acute infections of various sensitive bacteria, such as respiratory tract infections in livestock (pneumonia, pharyngitis, bronchitis), urinary tract infections, bovine influenza, actinomycosis, leptospirosis, bacterial gastroenteritis, cryptogenic Sexual mastitis, tuberculous mastitis (hard lump), mastitis and respiratory diseases of poultry (infectious rhinitis, etc.), bacterial enteritis, etc. It can also be used to control acute outbreaks of dairy cattle tuberculosis.



  Streptomycin sulfate is also used in the treatment of tularemia, plague, severe brucellosis, and melioidosis (often in combination with tetracycline or chloramphenicol). It is also used in the second-line treatment of tuberculosis, and is often used in combination with other anti-tuberculosis drugs.



  Streptomycin sulfate is currently widely used in vegetables, fruit trees, grains and other crops. The main control objects are antibiotic fungicides for soft rot, canker, bacterial blight, brown spot and rot. And streptomycin sulfate also has a systemic effect, which can penetrate into the body of green plants and transport it to other locations. Low toxicity to humans and livestock, and low toxicity to fish and aquatic organisms. It is suitable for sprayers, and can also be used for root irrigation and sterilization of soaked seeds. It is an ideal drug for controlling bacterial diseases at present.



The Streptomycin Sulfate Side Effects

  Although streptomycin sulfate has low toxicity to humans and animals, excessive concentrations can cause adverse reactions such as dizziness, headache, numbness around the lips or face, and excessive poisoning can cause numbness in the limbs, tremors, nausea, tinnitus, hearing loss, and even produce permanent deafness.

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